A threshold for high-level surface ROR1 (ROR1-Hi) was established in the training set that could distinguish cases into ROR1-Hi vs ROR1-Lo subgroups that differed significantly in their median time from diagnosis to initial treatment, or treatment-free survival (TFS).
26 Cases were randomly assigned to a training set or validation set of 797 or 771 patients, respectively. 43 This association between high-level expression of ROR1 and adverse outcome was established in a subsequent study of 1568 patients by the CLL Research Consortium. 42 Similarly, transgenic B-cell expression of ROR1 accelerates development of leukemia and shortens survival of Eμ-TCL1-transgenic mice, which develop a CD5 B-cell leukemia that mimics CLL.
In a study of 20 patients, Daneshmanesh and colleagues found patients with CLL cells that had high levels of ROR1 were more likely to have progressive disease than were those with CLL with low levels of ROR1.
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